| First Author | Wang S | Year | 1998 |
| Journal | Cell | Volume | 92 |
| Issue | 4 | Pages | 501-9 |
| PubMed ID | 9491891 | Mgi Jnum | J:46167 |
| Mgi Id | MGI:1197206 | Doi | 10.1016/s0092-8674(00)80943-5 |
| Citation | Wang S, et al. (1998) Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell 92(4):501-9 |
| abstractText | We report here the inactivation of a member of the Ice/Ced-3 (caspase) family of cell death genes, casp-11, by gene targeting. Like Ice-deficient mice, casp-11 mutant mice are resistant to endotoxic shock induced by lipopolysaccharide. Production of both IL-1alpha and IL-1beta after lipopolysaccharide stimulation, a crucial event during septic shock and an indication of ICE activation, is blocked in casp-11 mutant mice. casp-11 mutant embryonic fibroblast cells are resistant to apoptosis induced by overexpression of ICE. Furthermore, we found that pro-caspase-11 physically interacts with pro-ICE in cells, and the expression of casp-11 is essential for activation of ICE. Our data suggest that caspase-11 is a component of ICE complex and is required for the activation of ICE. |
