| First Author | Kühn R | Year | 1995 |
| Journal | Science | Volume | 269 |
| Issue | 5229 | Pages | 1427-9 |
| PubMed ID | 7660125 | Mgi Jnum | J:67927 |
| Mgi Id | MGI:1931702 | Doi | 10.1126/science.7660125 |
| Citation | Kuhn R, et al. (1995) Inducible gene targeting in mice. Science 269(5229):1427-9 |
| abstractText | A method of gene targeting that allows the inducible inactivation of a target gene in mice is presented. The method uses an interferon-responsive promoter to control the expression of Cre recombinase. Here, Cre was used to delete a segment of the DNA polymerase beta gene flanked by IoxP recombinase recognition sites. Deletion was complete in liver and nearly complete in lymphocytes within a few days, whereas partial deletion was obtained in other tissues. This method can be used for the inducible inactivation of any other gene in vivo. |
