| First Author | Vegiopoulos A | Year | 2006 |
| Journal | Blood | Volume | 107 |
| Issue | 12 | Pages | 4703-10 |
| PubMed ID | 16484593 | Mgi Jnum | J:132864 |
| Mgi Id | MGI:3777062 | Doi | 10.1182/blood-2005-07-2968 |
| Citation | Vegiopoulos A, et al. (2006) Coordination of erythropoiesis by the transcription factor c-Myb. Blood 107(12):4703-10 |
| abstractText | The involvement of the transcription factor c-Myb in promoting the proliferation and inhibition of erythroid cell differentiation has been established in leukemia cell models. The anemia phenotype observed in c-myb knockout and knockdown mice highlights a critical role for c-Myb in erythropoiesis. However, determining the reason for the failure of erythropoiesis in these mice and the precise function of c-Myb in erythroid progenitors remains elusive. We examined erythroid development under conditions of reduced c-Myb protein levels and report an unexpected role for c-Myb in the promotion of commitment to the erythroid lineage and progression to erythroblast stages. c-myb knockdown erythroid colony-forming unit (CFU-E) stage progenitors displayed an immature phenotype and aberrant expression of several hematopoietic regulators. To extend our findings, we analyzed the response of normal enriched erythroid progenitors to inducible disruption of a floxed c-myb allele. In agreement with the c-myb knockdown phenotype, we show that c-Myb is strictly required for expression of the c-Kit receptor in erythroid cells. |
