| First Author | Welner RS | Year | 2013 |
| Journal | Blood | Volume | 121 |
| Issue | 20 | Pages | 4073-81 |
| PubMed ID | 23547051 | Mgi Jnum | J:198203 |
| Mgi Id | MGI:5495854 | Doi | 10.1182/blood-2012-10-463448 |
| Citation | Welner RS, et al. (2013) C/EBPalpha is required for development of dendritic cell progenitors. Blood 121(20):4073-81 |
| abstractText | Dendritic cells (DCs) are master regulators of the immune system, but molecular regulation of early DC differentiation has been poorly understood. Here, we report that the transcription factor C/EBPalpha coordinates the development of progenitor cells required for production of multiple categories of DCs. C/EBPalpha was needed for differentiation from stem/progenitor cells to common DC progenitors (CDPs), but not for transition of CDP to mature DCs. C/EBPalpha deletion in mature DCs did not affect their numbers or function, suggesting that this transcription factor is not needed for maintenance of DCs in lymphoid tissues. ChIP-seq and microarrays were used to identify candidate genes regulated by C/EBPalpha and required for DC formation. Genes previously shown to be critical for DC formation were bound by C/EBPalpha, and their expression was decreased in the earliest hematopoietic compartments in the absence of C/EBPalpha. These data indicate that C/EBPalpha is important for the earliest stages of steady-state DC differentiation. |
