| First Author | Simon C | Year | 2012 |
| Journal | Genes Dev | Volume | 26 |
| Issue | 7 | Pages | 651-6 |
| PubMed ID | 22431509 | Mgi Jnum | J:182211 |
| Mgi Id | MGI:5315022 | Doi | 10.1101/gad.186411.111 |
| Citation | Simon C, et al. (2012) A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia. Genes Dev 26(7):651-6 |
| abstractText | In this study, we show the high frequency of spontaneous gammadelta T-cell leukemia (T-ALL) occurrence in mice with biallelic deletion of enhancer of zeste homolog 2 (Ezh2). Tumor cells show little residual H3K27 trimethylation marks compared with controls. EZH2 is a component of the PRC2 Polycomb group protein complex, which is associated with DNA methyltransferases. Using next-generation sequencing, we identify alteration in gene expression levels of EZH2 and acquired mutations in PRC2-associated genes (DNMT3A and JARID2) in human adult T-ALL. Together, these studies document that deregulation of EZH2 and associated genes leads to the development of mouse, and likely human, T-ALL. |
