| First Author | Keren Z | Year | 2011 |
| Journal | Blood | Volume | 117 |
| Issue | 11 | Pages | 3104-12 |
| PubMed ID | 21228330 | Mgi Jnum | J:170519 |
| Mgi Id | MGI:4946599 | Doi | 10.1182/blood-2010-09-307983 |
| Citation | Keren Z, et al. (2011) B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging. Blood 117(11):3104-12 |
| abstractText | Aging is associated with a decline in B-lymphopoiesis in the bone marrow and accumulation of long-lived B cells in the periphery. These changes decrease the body's ability to mount protective antibody responses. We show here that age-related changes in the B lineage are mediated by the accumulating long-lived B cells. Thus, depletion of B cells in old mice was followed by expansion of multipotent primitive progenitors and common lymphoid progenitors, a revival of B-lymphopoiesis in the bone marrow, and generation of a rejuvenated peripheral compartment that enhanced the animal's immune responsiveness to antigenic stimulation. Collectively, our results suggest that immunosenescence in the B-lineage is not irreversible and that depletion of the long-lived B cells in old mice rejuvenates the B-lineage and enhances immune competence. |
