| First Author | Lassen LB | Year | 2013 |
| Journal | Cell Tissue Res | Volume | 352 |
| Issue | 3 | Pages | 695-705 |
| PubMed ID | 23644740 | Mgi Jnum | J:205027 |
| Mgi Id | MGI:5543886 | Doi | 10.1007/s00441-013-1618-6 |
| Citation | Lassen LB, et al. (2013) Septin9 is involved in T-cell development and CD8+ T-cell homeostasis. Cell Tissue Res 352(3):695-705 |
| abstractText | SEPTIN9 (SEPT9) is a filament-forming protein involved in numerous cellular processes. We have used a conditional knock out allele of Sept9 to specifically delete Sept9 in T-cells. As shown by fluorescence-activated cell sorting, loss of Sept9 at an early thymocyte stage in the thymus results in increased numbers of double-negative cells indicating that SEPT9 is involved in the transition from the double-negative stage during T-cell development. Accordingly, the relative numbers of mature T-cells in the periphery are decreased in mice with a T-cell-specific deletion of Sept9. Proliferation of Sept9-deleted CD8(+) T-cells from the spleen is decreased upon stimulation in culture. The altered T-cell homeostasis caused by the loss of Sept9 results in an increase of CD8(+) central memory T-cells. |
