| First Author | Hock H | Year | 2004 |
| Journal | Genes Dev | Volume | 18 |
| Issue | 19 | Pages | 2336-41 |
| PubMed ID | 15371326 | Mgi Jnum | J:93052 |
| Mgi Id | MGI:3055650 | Doi | 10.1101/gad.1239604 |
| Citation | Hock H, et al. (2004) Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev 18(19):2336-41 |
| abstractText | Hematopoietic stem cells (HSCs) sustain blood formation throughout life. Pathways regulating maintenance of adult HSCs are largely unknown. Here we report that the Ets-related transcription factor Tel/Etv6, the product of a locus frequently involved in translocations in leukemia, is a selective regulator of HSC survival. Following inactivation of Tel/Etv6, HSCs are lost in the adult bone marrow but their progeny are unaffected and transiently sustain blood formation. Accordingly, absence of Tel/Etv6 after lineage commitment is ostensibly without consequence except for unexpected impairment of maturation of megakaryocytes. Thus, we establish Tel/Etv6 as a selective and essential regulator of postembryonic HSCs. |
