| First Author | Han KA | Year | 2020 |
| Journal | Mol Brain | Volume | 13 |
| Issue | 1 | Pages | 94 |
| PubMed ID | 32552840 | Mgi Jnum | J:317725 |
| Mgi Id | MGI:6844739 | Doi | 10.1186/s13041-020-00629-x |
| Citation | Han KA, et al. (2020) Receptor protein tyrosine phosphatase delta is not essential for synapse maintenance or transmission at hippocampal synapses. Mol Brain 13(1):94 |
| abstractText | Members of the leukocyte common antigen-related receptor protein tyrosine phosphatase (LAR-RPTP) family, comprising PTPsigma, PTPdelta and LAR, are key hubs for presynaptic assembly and differentiation in vertebrate neurons. However, roles of individual LAR-RPTP members have not been investigated using member-specific conditional knockout mice. Here, we show that loss of PTPdelta had no overt effect on synapse development in mouse cultured hippocampal neurons. Moreover, loss of PTPdelta in presynaptic CA1 hippocampal neurons did not influence neurotransmitter release in subicular pyramidal neurons, suggesting that PTPdelta is not critical for presynaptic function in vivo. Our results demonstrate that PTPdelta is not essential for synapse maintenance or transmission, at least in the mouse hippocampus, and underscore the importance of using sophisticated genetic approaches to confirm the roles of synaptic proteins. |
