| First Author | Sabio G | Year | 2010 |
| Journal | Genes Dev | Volume | 24 |
| Issue | 3 | Pages | 256-64 |
| PubMed ID | 20080940 | Mgi Jnum | J:156939 |
| Mgi Id | MGI:4422118 | Doi | 10.1101/gad.1878510 |
| Citation | Sabio G, et al. (2010) Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev 24(3):256-64 |
| abstractText | The cJun N-terminal kinase 1 (JNK1) is implicated in diet-induced obesity. Indeed, germline ablation of the murine Jnk1 gene prevents diet-induced obesity. Here we demonstrate that selective deficiency of JNK1 in the murine nervous system is sufficient to suppress diet-induced obesity. The failure to increase body mass is mediated, in part, by increased energy expenditure that is associated with activation of the hypothalamic-pituitary-thyroid axis. Disruption of thyroid hormone function prevents the effects of nervous system JNK1 deficiency on body mass. These data demonstrate that the hypothalamic-pituitary-thyroid axis represents an important target of metabolic signaling by JNK1. |
