| First Author | Shin Yim Y | Year | 2017 |
| Journal | Nature | Volume | 549 |
| Issue | 7673 | Pages | 482-487 |
| PubMed ID | 28902835 | Mgi Jnum | J:250005 |
| Mgi Id | MGI:6095379 | Doi | 10.1038/nature23909 |
| Citation | Shin Yim Y, et al. (2017) Reversing behavioural abnormalities in mice exposed to maternal inflammation. Nature 549(7673):482-487 |
| abstractText | Viral infection during pregnancy is correlated with increased frequency of neurodevelopmental disorders, and this is studied in mice prenatally subjected to maternal immune activation (MIA). We previously showed that maternal T helper 17 cells promote the development of cortical and behavioural abnormalities in MIA-affected offspring. Here we show that cortical abnormalities are preferentially localized to a region encompassing the dysgranular zone of the primary somatosensory cortex (S1DZ). Moreover, activation of pyramidal neurons in this cortical region was sufficient to induce MIA-associated behavioural phenotypes in wild-type animals, whereas reduction in neural activity rescued the behavioural abnormalities in MIA-affected offspring. Sociability and repetitive behavioural phenotypes could be selectively modulated according to the efferent targets of S1DZ. Our work identifies a cortical region primarily, if not exclusively, centred on the S1DZ as the major node of a neural network that mediates behavioural abnormalities observed in offspring exposed to maternal inflammation. |
