| First Author | Zocchi L | Year | 2012 |
| Journal | Epigenetics | Volume | 7 |
| Issue | 7 | Pages | 695-700 |
| PubMed ID | 22677942 | Mgi Jnum | J:323994 |
| Mgi Id | MGI:7264825 | Doi | 10.4161/epi.20733 |
| Citation | Zocchi L, et al. (2012) SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression. Epigenetics 7(7):695-700 |
| abstractText | Methyl-CpG binding protein 2 (MeCP2) binds methylated cytosines at CpG sites on DNA and it is thought to function as a critical epigenetic regulator. Mutations in the MeCP2 gene have been associated to Rett syndrome, a human neurodevelopmental disorder. Here we show that MeCP2 is acetylated by p300 and that SIRT1 mediates its deacetylation. SIRT1, the mammalian homologue of Sir2 in yeast, is a nicotinamide-adenine dinucleotide (NAD(+))-dependent histone deacetylase that belongs to the family of HDAC class III sirtuins. Importantly, SIRT1 has been shown to play a critical role in synaptic plasticity and memory formation. This study reveals a functional interplay between two critical epigenetic regulators, MeCP2 and SIRT1, which controls MeCP2 binding activity to the brain-derived neurotrophic factor (BDNF) promoter in a specific region of the brain. |
