| First Author | Newbern JM | Year | 2011 |
| Journal | Neuron | Volume | 69 |
| Issue | 1 | Pages | 91-105 |
| PubMed ID | 21220101 | Mgi Jnum | J:264453 |
| Mgi Id | MGI:6196959 | Doi | 10.1016/j.neuron.2010.12.003 |
| Citation | Newbern JM, et al. (2011) Specific functions for ERK/MAPK signaling during PNS development. Neuron 69(1):91-105 |
| abstractText | We have established functions of the stimulus-dependent MAPKs, ERK1/2 and ERK5, in DRG, motor neuron, and Schwann cell development. Surprisingly, many aspects of early DRG and motor neuron development were found to be ERK1/2 independent, and Erk5 deletion had no obvious effect on embryonic PNS. In contrast, Erk1/2 deletion in developing neural crest resulted in peripheral nerves that were devoid of Schwann cell progenitors, and deletion of Erk1/2 in Schwann cell precursors caused disrupted differentiation and marked hypomyelination of axons. The Schwann cell phenotypes are similar to those reported in neuregulin-1 and ErbB mutant mice, and neuregulin effects could not be elicited in glial precursors lacking Erk1/2. ERK/MAPK regulation of myelination was specific to Schwann cells, as deletion in oligodendrocyte precursors did not impair myelin formation, but reduced precursor proliferation. Our data suggest a tight linkage between developmental functions of ERK/MAPK signaling and biological actions of specific RTK-activating factors. |
