| First Author | DuBose AJ | Year | 2012 |
| Journal | Proc Natl Acad Sci U S A | Volume | 109 |
| Issue | 9 | Pages | 3446-50 |
| PubMed ID | 22331910 | Mgi Jnum | J:182162 |
| Mgi Id | MGI:5314849 | Doi | 10.1073/pnas.1115057109 |
| Citation | DuBose AJ, et al. (2012) Temporal and developmental requirements for the Prader-Willi imprinting center. Proc Natl Acad Sci U S A 109(9):3446-50 |
| abstractText | Imprinted gene expression associated with Prader-Willi syndrome (PWS) and Angelman syndrome (AS) is controlled by two imprinting centers (ICs), the PWS-IC and the AS-IC. The PWS-IC operates in cis to activate transcription of genes that are expressed exclusively from the paternal allele. We have created a conditional allele of the PWS-IC to investigate its developmental activity. Deletion of the paternal PWS-IC in the embryo before implantation abolishes expression of the paternal-only genes in the neonatal brain. Surprisingly, deletion of the PWS-IC in early brain progenitors does not affect the subsequent imprinted status of PWS/AS genes in the newborn brain. These results indicate that the PWS-IC functions to protect the paternal epigenotype at the epiblast stage of development but is dispensable thereafter. |
