| First Author | Taguchi A | Year | 2007 |
| Journal | Science | Volume | 317 |
| Issue | 5836 | Pages | 369-72 |
| PubMed ID | 17641201 | Mgi Jnum | J:123171 |
| Mgi Id | MGI:3717310 | Doi | 10.1126/science.1142179 |
| Citation | Taguchi A, et al. (2007) Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317(5836):369-72 |
| abstractText | Reduced insulin-like signaling extends the life span of Caenorhabditis elegans and Drosophila. Here, we show that, in mice, less insulin receptor substrate-2 (Irs2) signaling throughout the body or just in the brain extended life span up to 18%. At 22 months of age, brain-specific Irs2 knockout mice were overweight, hyperinsulinemic, and glucose intolerant; however, compared with control mice, they were more active and displayed greater glucose oxidation, and during meals they displayed stable superoxide dismutase-2 concentrations in the hypothalamus. Thus, less Irs2 signaling in aging brains can promote healthy metabolism, attenuate meal-induced oxidative stress, and extend the life span of overweight and insulin-resistant mice. |
