| First Author | Odajima J | Year | 2011 |
| Journal | Dev Cell | Volume | 21 |
| Issue | 4 | Pages | 655-68 |
| PubMed ID | 21944720 | Mgi Jnum | J:178882 |
| Mgi Id | MGI:5300448 | Doi | 10.1016/j.devcel.2011.08.009 |
| Citation | Odajima J, et al. (2011) Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Dev Cell 21(4):655-68 |
| abstractText | Cyclin E is a component of the core cell cycle machinery, and it drives cell proliferation by regulating entry and progression of cells through the DNA synthesis phase. Cyclin E expression is normally restricted to proliferating cells. However, high levels of cyclin E are expressed in the adult brain. The function of cyclin E in quiescent, postmitotic nervous system remains unknown. Here we use a combination of in vivo quantitative proteomics and analyses of cyclin E knockout mice to demonstrate that in terminally differentiated neurons cyclin E forms complexes with Cdk5 and controls synapse function by restraining Cdk5 activity. Ablation of cyclin E led to a decreased number of synapses, reduced number and volume of dendritic spines, and resulted in impaired synaptic plasticity and memory formation in cyclin E-deficient animals. These results reveal a cell cycle-independent role for a core cell cycle protein, cyclin E, in synapse function and memory. |
