| First Author | Đặng TC | Year | 2019 |
| Journal | Cell Rep | Volume | 27 |
| Issue | 4 | Pages | 1073-1089.e5 |
| PubMed ID | 31018125 | Mgi Jnum | J:280978 |
| Mgi Id | MGI:6376357 | Doi | 10.1016/j.celrep.2019.03.084 |
| Citation | Dang TC, et al. (2019) Powerful Homeostatic Control of Oligodendroglial Lineage by PDGFRalpha in Adult Brain. Cell Rep 27(4):1073-1089.e5 |
| abstractText | Oligodendrocyte progenitor cells (OPCs) are widely distributed cells of ramified morphology in adult brain that express PDGFRalpha and NG2. They retain mitotic activities in adulthood and contribute to oligodendrogenesis and myelin turnover; however, the regulatory mechanisms of their cell dynamics in adult brain largely remain unknown. Here, we found that global Pdgfra inactivation in adult mice rapidly led to elimination of OPCs due to synchronous maturation toward oligodendrocytes. Surprisingly, OPC densities were robustly reconstituted by the active expansion of Nestin(+) immature cells activated in meninges and brain parenchyma, as well as a few OPCs that escaped from Pdgfra inactivation. The multipotent immature cells were induced in the meninges of Pdgfra-inactivated mice, but not of control mice. Our findings revealed powerful homeostatic control of adult OPCs, engaging dual cellular sources of adult OPC formation. These properties of the adult oligodendrocyte lineage and the alternative OPC source may be exploited in regenerative medicine. |
