| First Author | Wiegreffe C | Year | 2015 |
| Journal | Neuron | Volume | 87 |
| Issue | 2 | Pages | 311-25 |
| PubMed ID | 26182416 | Mgi Jnum | J:227426 |
| Mgi Id | MGI:5700454 | Doi | 10.1016/j.neuron.2015.06.023 |
| Citation | Wiegreffe C, et al. (2015) Bcl11a (Ctip1) Controls Migration of Cortical Projection Neurons through Regulation of Sema3c. Neuron 87(2):311-25 |
| abstractText | During neocortical development, neurons undergo polarization, oriented migration, and layer-type-specific differentiation. The transcriptional programs underlying these processes are not completely understood. Here, we show that the transcription factor Bcl11a regulates polarity and migration of upper layer neurons. Bcl11a-deficient late-born neurons fail to correctly switch from multipolar to bipolar morphology, resulting in impaired radial migration. We show that the expression of Sema3c is increased in migrating Bcl11a-deficient neurons and that Bcl11a is a direct negative regulator of Sema3c transcription. In vivo gain-of-function and rescue experiments demonstrate that Sema3c is a major downstream effector of Bcl11a required for the cell polarity switch and for the migration of upper layer neurons. Our data uncover a novel Bcl11a/Sema3c-dependent regulatory pathway used by migrating cortical neurons. |
