| First Author | Hutter K | Year | 2022 |
| Journal | Life Sci Alliance | Volume | 5 |
| Issue | 8 | PubMed ID | 35459737 |
| Mgi Jnum | J:361360 | Mgi Id | MGI:7275731 |
| Doi | 10.26508/lsa.202101303 | Citation | Hutter K, et al. (2022) The miR-26 family regulates early B cell development and transformation. Life Sci Alliance 5(8):e202101303 |
| abstractText | MiRNAs are small noncoding RNAs that promote the sequence-specific repression of their respective target genes, thereby regulating diverse physiological as well as pathological processes. Here, we identify a novel role of the miR-26 family in early B cell development. We show that enhanced expression of miR-26 family members potently blocks the pre-B to immature B cell transition, promotes pre-B cell expansion and eventually enables growth factor independency. Mechanistically, this is at least partially mediated by direct repression of the tumor-suppressor Pten, which consequently enhances PI3K-AKT signaling. Conversely, limiting miR-26 activity in a more physiological loss-of-function approach counteracts proliferation and enhances pre-B cell differentiation in vitro as well as in vivo. We therefore postulate a rheostat-like role for the miR-26 family in progenitor B cells, with an increase in mature miR-26 levels signaling cell expansion, and facilitating pre-B to the immature B cell progression when reduced. |
