| First Author | Gazit R | Year | 2006 |
| Journal | Nat Immunol | Volume | 7 |
| Issue | 5 | Pages | 517-23 |
| PubMed ID | 16565719 | Mgi Jnum | J:112394 |
| Mgi Id | MGI:3656196 | Doi | 10.1038/ni1322 |
| Citation | Gazit R, et al. (2006) Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nat Immunol 7(5):517-23 |
| abstractText | The elimination of viruses and tumors by natural killer cells is mediated by specific natural killer cell receptors. To study the in vivo function of a principal activating natural killer cell receptor, NCR1 (NKp46 in humans), we replaced the gene encoding this receptor (Ncr1) with a green fluorescent protein reporter cassette. There was enhanced spread of certain tumors in 129/Sv but not C57BL/6 Ncr1(gfp/gfp) mice, and influenza virus infection was lethal in both 129/Sv and C57BL/6 Ncr1(gfp/gfp) mice. We noted accumulation of natural killer cells at the site of influenza infection by tracking the green fluorescent protein. Our results demonstrate a critical function for Ncr1 in the in vivo eradication of influenza virus. |
