| First Author | Miller BR | Year | 2009 |
| Journal | Nat Neurosci | Volume | 12 |
| Issue | 4 | Pages | 387-9 |
| PubMed ID | 19287387 | Mgi Jnum | J:188476 |
| Mgi Id | MGI:5440717 | Doi | 10.1038/nn.2290 |
| Citation | Miller BR, et al. (2009) A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration. Nat Neurosci 12(4):387-9 |
| abstractText | Axon degeneration underlies many common neurological disorders, but the signaling pathways that orchestrate axon degeneration are unknown. We found that dual leucine kinase (DLK) [corrected to add (DLK) abbreviation] promoted degeneration of severed axons in Drosophila and mice, and that its target, c-Jun N-terminal kinase, promoted degeneration locally in axons as they committed to degenerate. This pathway also promoted degeneration after chemotherapy exposure and may be a component of a general axon self-destruction program. |
