| First Author | Kim MV | Year | 2013 |
| Journal | Immunity | Volume | 39 |
| Issue | 2 | Pages | 286-97 |
| PubMed ID | 23932570 | Mgi Jnum | J:208232 |
| Mgi Id | MGI:5562508 | Doi | 10.1016/j.immuni.2013.07.013 |
| Citation | Kim MV, et al. (2013) The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection. Immunity 39(2):286-97 |
| abstractText | Memory T cells protect hosts from pathogen reinfection, but how these cells emerge from a pool of antigen-experienced T cells is unclear. Here, we show that mice lacking the transcription factor Foxo1 in activated CD8+ T cells have defective secondary, but not primary, responses to Listeria monocytogenes infection. Compared to short-lived effector T cells, memory-precursor T cells expressed higher amounts of Foxo1, which promoted their generation and maintenance. Chromatin immunoprecipitation sequencing revealed the transcription factor Tcf7 and the chemokine receptor Ccr7 as Foxo1-bound target genes, which have critical functions in central-memory T cell differentiation and trafficking. These findings demonstrate that Foxo1 is selectively incorporated into the genetic program that regulates memory CD8+ T cell responses to infection. |
