| First Author | Messmer JM | Year | 2024 |
| Journal | Immunity | Volume | 57 |
| Issue | 11 | Pages | 2688-2703.e11 |
| PubMed ID | 39368486 | Mgi Jnum | J:358144 |
| Mgi Id | MGI:7779483 | Doi | 10.1016/j.immuni.2024.09.003 |
| Citation | Messmer JM, et al. (2024) T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vessels. Immunity 57(11):2688-2703.e11 |
| abstractText | To improve immunotherapy for brain tumors, it is important to determine the principal intracranial site of T cell recruitment from the bloodstream and their intracranial route to brain tumors. Using intravital microscopy in mouse models of intracranial melanoma, we discovered that circulating T cells preferably adhered and extravasated at a distinct type of venous blood vessel in the tumor vicinity, peritumoral venous vessels (PVVs). Other vascular structures were excluded as alternative T cell routes to intracranial melanomas. Anti-PD-1/CTLA-4 immune checkpoint inhibitors increased intracranial T cell motility, facilitating migration from PVVs to the tumor and subsequently inhibiting intracranial tumor growth. The endothelial adhesion molecule ICAM-1 was particularly expressed on PVVs, and, in samples of human brain metastases, ICAM-1 positivity of PVV-like vessels correlated with intratumoral T cell infiltration. These findings uncover a distinct mechanism by which the immune system can access and control brain tumors and potentially influence other brain pathologies. |
