| First Author | Bender TP | Year | 2004 |
| Journal | Nat Immunol | Volume | 5 |
| Issue | 7 | Pages | 721-9 |
| PubMed ID | 15195090 | Mgi Jnum | J:91122 |
| Mgi Id | MGI:3045997 | Doi | 10.1038/ni1085 |
| Citation | Bender TP, et al. (2004) Critical functions for c-Myb at three checkpoints during thymocyte development. Nat Immunol 5(7):721-9 |
| abstractText | The transcription factor c-Myb is expressed throughout T cell development in the thymus. However, little is understood about c-Myb function because of the embryonic lethality of traditional Myb-null mutations. Using tissue-specific deletion to abrogate c-Myb expression at distinct stages of T cell development, we identify three points at which c-Myb activity is required for normal T cell differentiation: transition through the double-negative 3 stage, survival of preselection CD4(+)CD8(+) thymocytes, and differentiation of CD4 thymocytes. Thus, c-Myb is essential at several stages during T cell development in the thymus. |
