| First Author | Twohig JP | Year | 2019 |
| Journal | Nat Immunol | Volume | 20 |
| Issue | 4 | Pages | 458-470 |
| PubMed ID | 30890796 | Mgi Jnum | J:282432 |
| Mgi Id | MGI:6380900 | Doi | 10.1038/s41590-019-0350-0 |
| Citation | Twohig JP, et al. (2019) Activation of naive CD4(+) T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4(+) T cells. Nat Immunol 20(4):458-470 |
| abstractText | The cytokine IL-6 controls the survival, proliferation and effector characteristics of lymphocytes through activation of the transcription factors STAT1 and STAT3. While STAT3 activity is an ever-present feature of IL-6 signaling in CD4(+) T cells, prior activation via the T cell antigen receptor limits IL-6's control of STAT1 in effector and memory populations. Here we found that phosphorylation of STAT1 in response to IL-6 was regulated by the tyrosine phosphatases PTPN2 and PTPN22 expressed in response to the activation of naive CD4(+) T cells. Transcriptomics and chromatin immunoprecipitation-sequencing (ChIP-seq) of IL-6 responses in naive and effector memory CD4(+) T cells showed how the suppression of STAT1 activation shaped the functional identity and effector characteristics of memory CD4(+) T cells. Thus, tyrosine phosphatases induced by the activation of naive T cells determine the way activated or memory CD4(+) T cells sense and interpret cytokine signals. |
