| First Author | Wei W | Year | 2023 |
| Journal | Cell Metab | Volume | 35 |
| Issue | 7 | Pages | 1261-1279.e11 |
| PubMed ID | 37141889 | Mgi Jnum | J:354809 |
| Mgi Id | MGI:7736451 | Doi | 10.1016/j.cmet.2023.04.011 |
| Citation | Wei W, et al. (2023) Organism-wide, cell-type-specific secretome mapping of exercise training in mice. Cell Metab 35(7):1261-1279.e11 |
| abstractText | There is a significant interest in identifying blood-borne factors that mediate tissue crosstalk and function as molecular effectors of physical activity. Although past studies have focused on an individual molecule or cell type, the organism-wide secretome response to physical activity has not been evaluated. Here, we use a cell-type-specific proteomic approach to generate a 21-cell-type, 10-tissue map of exercise training-regulated secretomes in mice. Our dataset identifies >200 exercise training-regulated cell-type-secreted protein pairs, the majority of which have not been previously reported. Pdgfra-cre-labeled secretomes were the most responsive to exercise training. Finally, we show anti-obesity, anti-diabetic, and exercise performance-enhancing activities for proteoforms of intracellular carboxylesterases whose secretion from the liver is induced by exercise training. |
