| First Author | Zhang Z | Year | 2020 |
| Journal | Eur J Immunol | Volume | 50 |
| Issue | 1 | Pages | 63-72 |
| PubMed ID | 31580477 | Mgi Jnum | J:284012 |
| Mgi Id | MGI:6390906 | Doi | 10.1002/eji.201948180 |
| Citation | Zhang Z, et al. (2020) Opposing peripheral fates of tissue-restricted self antigen-specific conventional and regulatory CD4+ T cells. Eur J Immunol 50(1):63-72 |
| abstractText | The development of self antigen-specific T cells is influenced by how the self antigen is expressed. Here, we created a mouse in which a model self antigen is conditionally expressed in different tissue environments. Using peptide:MHCII tetramer-based cell enrichment methods, we examined the development of corresponding endogenous self antigen-specific CD4+ T cell populations. While ubiquitous self antigen expression resulted in efficient deletion of self antigen-specific T cells in the thymus, some tissue-restricted expression patterns resulted in partial deletion of the population in peripheral lymphoid organs. Deletion specifically affected Foxp3- conventional T cells (Tconv) with a bias towards high avidity TCR expressing cells in the case of thymic, but not peripheral deletion. In contrast, Foxp3+ Treg exhibited elevated frequencies with increased TCR avidity. T cells surviving deletion were functionally impaired, with Tconv cells exhibiting more impairment than Tregs. Collectively, our results illustrate how postthymic recognition of tissue-restricted self antigens results in opposing developmental fates for Tconv and Treg cell subsets. |
