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Publication : Prevention of steatosis by hepatic JNK1.

First Author  Sabio G Year  2009
Journal  Cell Metab Volume  10
Issue  6 Pages  491-8
PubMed ID  19945406 Mgi Jnum  J:155978
Mgi Id  MGI:4418417 Doi  10.1016/j.cmet.2009.09.007
Citation  Sabio G, et al. (2009) Prevention of steatosis by hepatic JNK1. Cell Metab 10(6):491-8
abstractText  Nonalcoholic steatosis (fatty liver) is a major cause of liver dysfunction that is associated with insulin resistance and metabolic syndrome. The cJun NH(2)-terminal kinase 1 (JNK1) signaling pathway is implicated in the pathogenesis of hepatic steatosis and drugs that target JNK1 may be useful for treatment of this disease. Indeed, mice with defects in JNK1 expression in adipose tissue are protected against hepatic steatosis. Here we report that mice with specific ablation of Jnk1 in hepatocytes exhibit glucose intolerance, insulin resistance, and hepatic steatosis. JNK1 therefore serves opposing actions in liver and adipose tissue to both promote and prevent hepatic steatosis. This finding has potential implications for the design of JNK1-selective drugs for the treatment of metabolic syndrome.
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