| First Author | Tsugawa Y | Year | 2019 |
| Journal | Biochem Biophys Res Commun | Volume | 511 |
| Issue | 3 | Pages | 592-596 |
| PubMed ID | 30826053 | Mgi Jnum | J:291100 |
| Mgi Id | MGI:6442680 | Doi | 10.1016/j.bbrc.2019.02.119 |
| Citation | Tsugawa Y, et al. (2019) Estrogen induces estrogen receptor alpha expression and hepatocyte proliferation in late pregnancy. Biochem Biophys Res Commun 511(3):592-596 |
| abstractText | Partial hepatectomy (PH) induces estradiol production, and then hepatocyte proliferation. Estradiol may play a role in triggering hepatocyte proliferation after PH. In this study, estradiol was injected to the Estrogen Receptor alpha (ERalpha) or ERbeta KO mice. No increased hepatocyte proliferation was observed in ERalpha KO mice, indicates that ERalpha is involved in estradiol-induced hepatocyte proliferation. The ERalpha and ERbeta KO mice are sterile, hence it is impossible to study ERalpha and ERbeta function during pregnancy when the estrogen levels are highest. Using conditional mutagenesis technique, we made ERalpha hepatocyte KO mice, which are fertile. We used these mice for analyzing the hepatocyte ERalpha function during pregnancy. However, in the control mice, the maternal hepatocyte was proliferated higher in late pregnancy, but no pregnancy-induced hepatocyte proliferation was observed in KO mice. Hence, we conclude that the maternal hepatocyte ERalpha is involved in estradiol-induced hepatocyte proliferation in late pregnancy. |
