| First Author | Bard-Chapeau EA | Year | 2014 |
| Journal | Nat Genet | Volume | 46 |
| Issue | 1 | Pages | 24-32 |
| PubMed ID | 24316982 | Mgi Jnum | J:205496 |
| Mgi Id | MGI:5545674 | Doi | 10.1038/ng.2847 |
| Citation | Bard-Chapeau EA, et al. (2014) Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model. Nat Genet 46(1):24-32 |
| abstractText | The most common risk factor for developing hepatocellular carcinoma (HCC) is chronic infection with hepatitis B virus (HBV). To better understand the evolutionary forces driving HCC, we performed a near-saturating transposon mutagenesis screen in a mouse HBV model of HCC. This screen identified 21 candidate early stage drivers and a very large number (2,860) of candidate later stage drivers that were enriched for genes that are mutated, deregulated or functioning in signaling pathways important for human HCC, with a striking 1,199 genes being linked to cellular metabolic processes. Our study provides a comprehensive overview of the genetic landscape of HCC. |
