| First Author | Dong C | Year | 1998 |
| Journal | Science | Volume | 282 |
| Issue | 5396 | Pages | 2092-5 |
| PubMed ID | 9851932 | Mgi Jnum | J:51510 |
| Mgi Id | MGI:1316842 | Doi | 10.1126/science.282.5396.2092 |
| Citation | Dong C, et al. (1998) Defective T cell differentiation in the absence of Jnk1. Science 282(5396):2092-5 |
| abstractText | The c-Jun NH2-terminal kinase (JNK) signaling pathway has been implicated in the immune response that is mediated by the activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. JNK activity observed in wild-type activated TH cells was severely reduced in TH cells from Jnk1-/- mice. The Jnk1-/- T cells hyperproliferated, exhibited decreased activation-induced cell death, and preferentially differentiated to TH2 cells. The enhanced production of TH2 cytokines by Jnk1-/- cells was associated with increased nuclear accumulation of the transcription factor NFATc. Thus, the JNK1 signaling pathway plays a key role in T cell receptor-initiated TH cell proliferation, apoptosis, and differentiation. |
