| First Author | Rempe D | Year | 2006 |
| Journal | Genesis | Volume | 44 |
| Issue | 1 | Pages | 44-9 |
| PubMed ID | 16419044 | Mgi Jnum | J:105271 |
| Mgi Id | MGI:3614598 | Doi | 10.1002/gene.20183 |
| Citation | Rempe D, et al. (2006) Synapsin I Cre transgene expression in male mice produces germline recombination in progeny. Genesis 44(1):44-9 |
| abstractText | The cre/LoxP system can produce conditional loss of gene function in specific cell types such as neurons. A transgenic mouse line, utilized by multiple studies, used the Synapsin I promoter to drive expression of cre (SynCre) to achieve neuronal-specific cre expression. Herein we describe that cre expression can also be observed in SynCre mice within the testes after being bred into a floxed transgenic mouse line. Cre transcript was expressed in testes resulting in recombination of the floxed substrate in testes. In the majority of cases, progeny of male SynCre mice inherited a germline recombined floxed allele, while this was never observed in progeny from female mice carrying the SynCre allele. This observation should alert investigators to a potential confound using these mice and enables male germ cell 'deletor' strategies. |
