| First Author | Hinoi E | Year | 2006 |
| Journal | Genes Dev | Volume | 20 |
| Issue | 21 | Pages | 2937-42 |
| PubMed ID | 17050674 | Mgi Jnum | J:114686 |
| Mgi Id | MGI:3689756 | Doi | 10.1101/gad.1482906 |
| Citation | Hinoi E, et al. (2006) Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium. Genes Dev 20(21):2937-42 |
| abstractText | The perichondrium, a structure made of undifferentiated mesenchymal cells surrounding growth plate cartilage, regulates chondrocyte maturation through poorly understood mechanisms. Analyses of loss- and gain-of-function models show that Twist-1, whose expression in cartilage is restricted to perichondrium, favors chondrocyte maturation in a Runx2-dependent manner. Runx2, in turn, enhances perichondrial expression of Fgf18, a regulator of chondrocyte maturation. Accordingly, compound heterozygous embryos for Runx2 and Fgf18 deletion display the same chondrocyte maturation phenotype as Fgf18-null embryos. This study identifies a transcriptional basis for the inhibition of chondrocyte maturation by perichondrium and reveals that Runx2 fulfills antagonistic functions during chondrogenesis. |
