Other
13 Authors
- Wang B,
- Chapman HA,
- Sun J,
- Finn PW,
- Bucala R,
- Huang X,
- Kitamoto S,
- Wolters PJ,
- Shi GP,
- David JR,
- Riese R,
- Leng L,
- Yang M
| First Author | Wang B | Year | 2006 |
| Journal | J Immunol | Volume | 177 |
| Issue | 9 | Pages | 5779-84 |
| PubMed ID | 17056501 | Mgi Jnum | J:140539 |
| Mgi Id | MGI:3814040 | Doi | 10.4049/jimmunol.177.9.5779 |
| Citation | Wang B, et al. (2006) Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses. J Immunol 177(9):5779-84 |
| abstractText | Increased levels of macrophage migration inhibitory factor (MIF) in serum, sputum, and bronchioalveolar lavage fluid (BALF) from asthmatic patients and time/dose-dependent expression of MIF in eosinophils in response to phorbol myristate acetate suggest the participation of MIF in airway inflammation. In this study, we examined inflammation in OVA-sensitized mouse lungs in wild-type and MIF-deficient mice (MIF(-/-)). We report increased MIF in the lung and BALF of sensitized wild-type mice. MIF(-/-) mice demonstrated significant reductions in serum IgE and alveolar inflammatory cell recruitment. Reduced Th1/Th2 cytokines and chemokines also were detected in serum or BALF from MIF(-/-) mice. Importantly, alveolar macrophages and mast cells, but not dendritic cells or splenocytes, from MIF(-/-) mice demonstrated impaired CD4+ T cell activation, and the reconstitution of wild-type mast cells in MIF(-/-) mice restored the phenotype of OVA-induced airway inflammation, revealing a novel and essential role of mast cell-derived MIF in experimentally induced airway allergic diseases. |
