| First Author | McKay EJ | Year | 2024 |
| Journal | Dis Model Mech | Volume | 17 |
| Issue | 6 | PubMed ID | 38756069 |
| Mgi Jnum | J:351188 | Mgi Id | MGI:7663042 |
| Doi | 10.1242/dmm.050561 | Citation | McKay EJ, et al. (2024) Female Alms1-deficient mice develop echocardiographic features of adult but not infantile Alstrom syndrome cardiomyopathy. Dis Model Mech 17(6) |
| abstractText | Alstrom syndrome (AS), a multisystem disorder caused by biallelic ALMS1 mutations, features major early morbidity and mortality due to cardiac complications. The latter are biphasic, including infantile dilated cardiomyopathy and distinct adult-onset cardiomyopathy, and poorly understood. We assessed cardiac function of Alms1 knockout (KO) mice by echocardiography. Cardiac function was unaltered in Alms1 global KO mice of both sexes at postnatal day 15 (P15) and 8 weeks. At 23 weeks, female - but not male - KO mice showed increased left atrial area and decreased isovolumic relaxation time, consistent with early restrictive cardiomyopathy, as well as reduced ejection fraction. No histological or transcriptional changes were seen in myocardium of 23-week-old female Alms1 global KO mice. Female mice with Pdgfra-Cre-driven Alms1 deletion in cardiac fibroblasts and in a small proportion of cardiomyocytes did not recapitulate the phenotype of global KO at 23 weeks. In conclusion, only female Alms1-deficient adult mice show echocardiographic evidence of cardiac dysfunction, consistent with the cardiomyopathy of AS. The explanation for sexual dimorphism remains unclear but might involve metabolic or endocrine differences between sexes. |
