| First Author | Ohsugi M | Year | 2008 |
| Journal | Cell | Volume | 132 |
| Issue | 5 | Pages | 771-82 |
| PubMed ID | 18329364 | Mgi Jnum | J:145315 |
| Mgi Id | MGI:3834300 | Doi | 10.1016/j.cell.2008.01.029 |
| Citation | Ohsugi M, et al. (2008) Kid-mediated chromosome compaction ensures proper nuclear envelope formation. Cell 132(5):771-82 |
| abstractText | Toward the end of mitosis, neighboring chromosomes gather closely to form a compact cluster. This is important for reassembling the nuclear envelope around the entire chromosome mass but not individual chromosomes. By analyzing mice and cultured cells lacking the expression of chromokinesin Kid/kinesin-10, we show that Kid localizes to the boundaries of anaphase and telophase chromosomes and contributes to the shortening of the anaphase chromosome mass along the spindle axis. Loss of Kid-mediated anaphase chromosome compaction often causes the formation of multinucleated cells, specifically at oocyte meiosis II and the first couple of mitoses leading to embryonic death. In contrast, neither male meiosis nor somatic mitosis after the morula-stage is affected by Kid deficiency. These data suggest that Kid-mediated anaphase/telophase chromosome compaction prevents formation of multinucleated cells. This protection is especially important during the very early stages of development, when the embryonic cells are rich in ooplasm. |
