| First Author | Hisatsune C | Year | 2013 |
| Journal | Transgenic Res | Volume | 22 |
| Issue | 6 | Pages | 1241-7 |
| PubMed ID | 23624740 | Mgi Jnum | J:207751 |
| Mgi Id | MGI:5559589 | Doi | 10.1007/s11248-013-9711-x |
| Citation | Hisatsune C, et al. (2013) Striatum-specific expression of Cre recombinase using the Gpr88 promoter in mice. Transgenic Res 22(6):1241-7 |
| abstractText | We generated a transgenic (Tg) mouse line expressing Cre recombinase under the control of the Gpr88 promoter within a bacterial artificial chromosome clone. We crossed the established Tg mice with reporter mice (CAG-CAT-Z Tg), which express Escherichia coli lacZ in response to Cre-mediated excision of the loxP-flanked chloramphenicol acetyltransferase gene, and examined the Cre activity in the Tg mouse brains by assessing beta-galactosidase activity. Cre activity was specifically detected in the caudate-putamen, nucleus accumbens, and olfactory tubercle of the Gpr88-Cre Tg mouse brain. Medium spiny neurons within the caudate-putamen exhibited Cre activity. Thus, Gpr88-Cre Tg mice could be a useful tool for analyzing the function of the basal ganglia by using Cre/loxP systems. |
