| First Author | Dumon KR | Year | 2001 |
| Journal | Proc Natl Acad Sci U S A | Volume | 98 |
| Issue | 6 | Pages | 3346-51 |
| PubMed ID | 11248081 | Mgi Jnum | J:68073 |
| Mgi Id | MGI:1932009 | Doi | 10.1073/pnas.061020098 |
| Citation | Dumon KR, et al. (2001) FHIT gene therapy prevents tumor development in Fhit-deficient mice. Proc Natl Acad Sci U S A 98(6):3346-51 |
| abstractText | The tumor suppressor gene FHIT spans a common fragile site and is highly susceptible to environmental carcinogens. FHIT inactivation and loss of expression is found in a large fraction of premaligant and malignant lesions. In this study, we were able to inhibit tumor development by oral gene transfer, using adenoviral or adenoassociated viral vectors expressing the human FHIT gene, in heterozygous Fhit(+/-) knockout mice, that are prone to tumor development after carcinogen exposure. We therefore suggest that FHIT gene therapy could be a novel clinical approach not only in treatment of early stages of cancer, but also in prevention of human cancer. |
