| First Author | Rakowski-Anderson T | Year | 2012 |
| Journal | Comp Med | Volume | 62 |
| Issue | 2 | Pages | 87-94 |
| PubMed ID | 22546913 | Mgi Jnum | J:321076 |
| Mgi Id | MGI:6882038 | Citation | Rakowski-Anderson T, et al. (2012) Fecal corticosterone levels in RCAN1 mutant mice. Comp Med 62(2):87-94 |
| abstractText | Regulator of calcineurin 1 (RCAN1) is related to the expression of human neurologic disorders such as Down syndrome, Alzheimer disease, and chromosome 21q deletion syndrome. We showed here that RCAN1-knockout mice exhibit reduced innate anxiety as indicated by the elevated-plus maze. To examine whether glucocorticoids contribute to this phenotype, we measured fecal corticosterone in male wildtype and RCAN1-knockout mice and in male and female transgenic mice with neuronal overexpression of RCAN1 (Tg-RCAN1(TG)). We found no difference in fecal corticosterone levels of RCAN1-knockout mice and their wildtype littermates. As expected, we found differences between sexes in fecal corticosterone levels. In addition, we found higher levels of excreted corticosterone in Tg-RCAN1(TG) female mice as compared with female wildtype mice. Our data indicate normal diurnal corticosterone production in RCAN1 mutant mice and do not suggest a causal role in either the cognitive or anxiety phenotypes exhibited by RCAN1-knockout mice. |
