| First Author | Schmidt-Supprian M | Year | 2003 |
| Journal | Immunity | Volume | 19 |
| Issue | 3 | Pages | 377-89 |
| PubMed ID | 14499113 | Mgi Jnum | J:85810 |
| Mgi Id | MGI:2677083 | Doi | 10.1016/s1074-7613(03)00237-1 |
| Citation | Schmidt-Supprian M, et al. (2003) Mature T cells depend on signaling through the IKK complex. Immunity 19(3):377-89 |
| abstractText | The transcription factor NF-kappaB is implicated in various aspects of T cell development and function. The IkappaB kinase (IKK) complex, consisting of two kinases, IKK1/alpha and IKK2/beta, and the NEMO/IKKgamma regulatory subunit, mediates NF-kappaB activation by most known stimuli. Adoptive transfer experiments had demonstrated that IKK1 and IKK2 are dispensable for T cell development. We show here that T lineage-specific deletion of IKK2 allows survival of naive peripheral T cells but interferes with the generation of regulatory and memory T cells. T cell-specific ablation of NEMO or replacement of IKK2 with a kinase-dead mutant prevent development of peripheral T cells altogether. Thus, IKK-induced NF-kappaB activation, mediated by either IKK1 or IKK2, is essential for the generation and survival of mature T cells, and IKK2 has an additional role in regulatory and memory T cell development. |
