| First Author | Rossi FM | Year | 2005 |
| Journal | Nat Immunol | Volume | 6 |
| Issue | 6 | Pages | 626-34 |
| PubMed ID | 15880112 | Mgi Jnum | J:98951 |
| Mgi Id | MGI:3580766 | Doi | 10.1038/ni1203 |
| Citation | Rossi FM, et al. (2005) Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1. Nat Immunol 6(6):626-34 |
| abstractText | The molecular mechanisms that direct the migration of early T lymphocyte progenitors to the thymus are unknown. We show here that P-selectin is expressed by thymic endothelium and that lymphoid progenitors in bone marrow and thymus bind P-selectin. Parabiosis, competitive thymus reconstitution and short-term homing assays indicated that P-selectin and its ligand PSGL-1 are functionally important components of the thymic homing process. Accordingly, thymi of mice lacking PSGL-1 contained fewer early thymic progenitors and had increased empty niches for prothymocytes compared with wild-type mice. Furthermore, the number of resident thymic progenitors controls thymic expression of P-selectin, suggesting that regulation of P-selectin expression by a thymic 'niche occupancy sensor' may be used to direct progenitor access. |
