| First Author | Webb LM | Year | 2017 |
| Journal | EMBO J | Volume | 36 |
| Issue | 16 | Pages | 2404-2418 |
| PubMed ID | 28716804 | Mgi Jnum | J:243847 |
| Mgi Id | MGI:5912626 | Doi | 10.15252/embj.201695345 |
| Citation | Webb LM, et al. (2017) Type I interferon is required for T helper (Th) 2 induction by dendritic cells. EMBO J 36(16):2404-2418 |
| abstractText | Type 2 inflammation is a defining feature of infection with parasitic worms (helminths), as well as being responsible for widespread suffering in allergies. However, the precise mechanisms involved in T helper (Th) 2 polarization by dendritic cells (DCs) are currently unclear. We have identified a previously unrecognized role for type I IFN (IFN-I) in enabling this process. An IFN-I signature was evident in DCs responding to the helminth Schistosoma mansoni or the allergen house dust mite (HDM). Further, IFN-I signaling was required for optimal DC phenotypic activation in response to helminth antigen (Ag), and efficient migration to, and localization with, T cells in the draining lymph node (dLN). Importantly, DCs generated from Ifnar1-/- mice were incapable of initiating Th2 responses in vivo These data demonstrate for the first time that the influence of IFN-I is not limited to antiviral or bacterial settings but also has a central role to play in DC initiation of Th2 responses. |
