| First Author | Aloni E | Year | 2018 |
| Journal | Neuroscience | Volume | 394 |
| Pages | 156-163 | PubMed ID | 30401654 |
| Mgi Jnum | J:271507 | Mgi Id | MGI:6279420 |
| Doi | 10.1016/j.neuroscience.2018.10.035 | Citation | Aloni E, et al. (2018) Learning Deficits in Adult Mitochondria Carrier Homolog 2 Forebrain Knockout Mouse. Neuroscience 394:156-163 |
| abstractText | Mitochondrial Carrier Homolog 2 (MTCH2) acts as a receptor for the BH3 interacting-domain death agonist (BID) in the mitochondrial outer membrane. Loss of MTCH2 affects mitochondria energy metabolism and function. MTCH2 forebrain conditional KO (MTCH2 BKO) display a deficit in hippocampus-dependent cognitive functions. Here we study age-related MTCH2 BKO behavioral and electrophysiological aspects of hippocampal functions. MTCH2 BKO exhibit impaired spatial but not motor learning and an impairment in long-term potentiation (LTP) in hippocampal slices. Moreover, MTCH2 BKO express an increase in activated microglia, in addition to a reduction in neuron density in the hippocampus, but do not express amyloid-beta plaques or neurofibrillary tangles. These results highlight the role of mitochondria in the normal hippocampus-dependent memory formation. |
