| First Author | Peyssonnaux C | Year | 2008 |
| Journal | J Invest Dermatol | Volume | 128 |
| Issue | 8 | Pages | 1964-8 |
| PubMed ID | 18323789 | Mgi Jnum | J:141616 |
| Mgi Id | MGI:3819036 | Doi | 10.1038/jid.2008.27 |
| Citation | Peyssonnaux C, et al. (2008) Critical role of HIF-1alpha in keratinocyte defense against bacterial infection. J Invest Dermatol 128(8):1964-8 |
| abstractText | Skin, the first barrier against invading microorganisms, is hypoxic, even under baseline conditions. The transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha, the principal regulator of cellular adaptation to low oxygen, is strongly expressed in skin epithelium. HIF-1alpha is now understood to play a key role in the bactericidal capacity of phagocytic cells such as macrophages and neutrophils. In the skin, keratinocytes provide a direct antibacterial activity through production of antimicrobial peptides, including cathelicidin. Here, we generate mice with a keratinocyte-specific deletion of HIF-1alpha and examine effects on intrinsic skin immunity. Keratinocyte HIF-1alpha is seen to provide protection against necrotic skin lesions produced by the pathogen group A Streptococcus. RNA interference studies reveal that HIF-1alpha regulation of keratinocyte cathelicidin production is critical to their antibacterial function. |
