| First Author | Wong EW | Year | 2019 |
| Journal | Learn Mem | Volume | 26 |
| Issue | 3 | Pages | 77-83 |
| PubMed ID | 30770464 | Mgi Jnum | J:294501 |
| Mgi Id | MGI:6456435 | Doi | 10.1101/lm.049072.118 |
| Citation | Wong EW, et al. (2019) Spatial memory formation requires netrin-1 expression by neurons in the adult mammalian brain. Learn Mem 26(3):77-83 |
| abstractText | Netrin-1 was initially characterized as an axon guidance molecule that is essential for normal embryonic neural development; however, many types of neurons continue to express netrin-1 in the postnatal and adult mammalian brain. Netrin-1 and the netrin receptor DCC are both enriched at synapses. In the adult hippocampus, activity-dependent secretion of netrin-1 by neurons potentiates glutamatergic synapse function, and is critical for long-term potentiation, an experimental cellular model of learning and memory. Here, we assessed the impact of neuronal expression of netrin-1 in the adult brain on behavior using tests of learning and memory. We show that adult mice exhibit impaired spatial memory following conditional deletion of netrin-1 from glutamatergic neurons in the hippocampus and neocortex. Further, we provide evidence that mice with conditional deletion of netrin-1 do not display aberrant anxiety-like phenotypes and show a reduction in self-grooming behavior. These findings reveal a critical role for netrin-1 expressed by neurons in the regulation of spatial memory formation. |
