| First Author | He X | Year | 2021 |
| Journal | Neuron | Volume | 109 |
| Issue | 6 | Pages | 1013-1028.e9 |
| PubMed ID | 33548174 | Mgi Jnum | J:307173 |
| Mgi Id | MGI:6707017 | Doi | 10.1016/j.neuron.2021.01.014 |
| Citation | He X, et al. (2021) Gating of hippocampal rhythms and memory by synaptic plasticity in inhibitory interneurons. Neuron 109(6):1013-1028.e9 |
| abstractText | Mental experiences can become long-term memories if the hippocampal activity patterns that encode them are broadcast during network oscillations. The activity of inhibitory neurons is essential for generating these neural oscillations, but molecular control of this dynamic process during learning remains unknown. Here, we show that hippocampal oscillatory strength positively correlates with excitatory monosynaptic drive onto inhibitory neurons (E-->I) in freely behaving mice. To establish a causal relationship between them, we identified gammaCaMKII as the long-sought mediator of long-term potentiation for E-->I synapses (LTPE-->I), which enabled the genetic manipulation of experience-dependent E-->I synaptic input/plasticity. Deleting gammaCaMKII in parvalbumin interneurons selectively eliminated LTPE-->I and disrupted experience-driven strengthening in theta and gamma rhythmicity. Behaviorally, this manipulation impaired long-term memory, for which the kinase activity of gammaCaMKII was required. Taken together, our data suggest that E-->I synaptic plasticity, exemplified by LTPE-->I, plays a gatekeeping role in tuning experience-dependent brain rhythms and mnemonic function. |
