| First Author | Chen-Engerer HJ | Year | 2019 |
| Journal | Nat Commun | Volume | 10 |
| Issue | 1 | Pages | 3223 |
| PubMed ID | 31324793 | Mgi Jnum | J:279425 |
| Mgi Id | MGI:6362429 | Doi | 10.1038/s41467-019-11207-8 |
| Citation | Chen-Engerer HJ, et al. (2019) Two types of functionally distinct Ca(2+) stores in hippocampal neurons. Nat Commun 10(1):3223 |
| abstractText | It is widely assumed that inositol trisphosphate (IP3) and ryanodine (Ry) receptors share the same Ca(2+) pool in central mammalian neurons. We now demonstrate that in hippocampal CA1 pyramidal neurons IP3- and Ry-receptors are associated with two functionally distinct intracellular Ca(2+) stores, respectively. While the IP3-sensitive Ca(2+) store refilling requires Orai2 channels, Ry-sensitive Ca(2+) store refilling involves voltage-gated Ca(2+) channels (VGCCs). Our findings have direct implications for the understanding of function and plasticity in these central mammalian neurons. |
