| First Author | Gu Z | Year | 2020 |
| Journal | Cell Rep | Volume | 31 |
| Issue | 10 | Pages | 107740 |
| PubMed ID | 32521265 | Mgi Jnum | J:300005 |
| Mgi Id | MGI:6489072 | Doi | 10.1016/j.celrep.2020.107740 |
| Citation | Gu Z, et al. (2020) Hippocampal Interneuronal alpha7 nAChRs Modulate Theta Oscillations in Freely Moving Mice. Cell Rep 31(10):107740 |
| abstractText | Muscarinic acetylcholine receptors (mAChRs) are critically involved in hippocampal theta generation, but much less is known about the role of nicotinic AChRs (nAChRs). Here we provide evidence that alpha7 nAChRs expressed on interneurons, particularly those in oriens lacunosum moleculare (OLM), also regulate hippocampal theta generation. Local hippocampal infusion of a selective alpha7 nAChR antagonist significantly reduces hippocampal theta power and impairs Y-maze spontaneous alternation performance in freely moving mice. By knocking out receptors in different neuronal subpopulations, we find that alpha7 nAChRs expressed in OLM interneurons regulate theta generation. Our in vitro slice studies indicate that alpha7 nAChR activation increases OLM neuron activity that, in turn, enhances pyramidal cell excitatory postsynaptic currents (EPSCs). Our study also suggests that mAChR activation promotes transient theta generation, while alpha7 nAChR activation facilitates future theta generation by similar stimulations, revealing a complex mechanism whereby cholinergic signaling modulates different aspects of hippocampal theta oscillations through different receptor subtypes. |
