| First Author | Li D | Year | 2019 |
| Journal | Front Cell Neurosci | Volume | 13 |
| Pages | 133 | PubMed ID | 31001090 |
| Mgi Jnum | J:277566 | Mgi Id | MGI:6316828 |
| Doi | 10.3389/fncel.2019.00133 | Citation | Li D, et al. (2019) Enhanced Expression of Secreted alpha-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice. Front Cell Neurosci 13:133 |
| abstractText | The klotho gene family consists of alpha-, beta-, and gamma-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. alpha-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular domain. Due to gene splicing, a short extracellular Klotho form can be expressed and secreted. Inactivation of alpha-Klotho leads to a phenotype that resembles accelerated aging, as the expression level of the alpha-Klotho protein in the hippocampal formation of mice decreases with age. Here, we show that intrahippocampal viral expression of secreted human alpha-Klotho alters social behavior and memory formation. Interestingly, overexpression of secreted human alpha-Klotho in the CA1 changed the nest-building behavior and improved object recognition, object location and passive avoidance memory. Moreover, alpha-Klotho overexpression increased hippocampal synaptic transmission in response to standardized stimulation strengths, altered paired-pulse facilitation of synaptic transmission, and enhanced activity-dependent synaptic plasticity. These results indicate that memory formation benefits from an augmented level of secreted alpha-Klotho. |
