| First Author | Lopes-Dos-Santos V | Year | 2018 |
| Journal | Neuron | Volume | 100 |
| Issue | 4 | Pages | 940-952.e7 |
| PubMed ID | 30344040 | Mgi Jnum | J:274923 |
| Mgi Id | MGI:6284896 | Doi | 10.1016/j.neuron.2018.09.031 |
| Citation | Lopes-Dos-Santos V, et al. (2018) Parsing Hippocampal Theta Oscillations by Nested Spectral Components during Spatial Exploration and Memory-Guided Behavior. Neuron 100(4):940-952.e7 |
| abstractText | Theta oscillations reflect rhythmic inputs that continuously converge to the hippocampus during exploratory and memory-guided behavior. The theta-nested operations that organize hippocampal spiking could either occur regularly from one cycle to the next or be tuned on a cycle-by-cycle basis. To resolve this, we identified spectral components nested in individual theta cycles recorded from the mouse CA1 hippocampus. Our single-cycle profiling revealed theta spectral components associated with different firing modulations and distinguishable ensembles of principal cells. Moreover, novel co-firing patterns of principal cells in theta cycles nesting mid-gamma oscillations were the most strongly reactivated in subsequent offline sharp-wave/ripple events. Finally, theta-nested spectral components were differentially altered by behavioral stages of a memory task; the 80-Hz mid-gamma component was strengthened during learning, whereas the 22-Hz beta, 35-Hz slow gamma, and 54-Hz mid-gamma components increased during retrieval. We conclude that cycle-to-cycle variability of theta-nested spectral components allows parsing of theta oscillations into transient operating modes with complementary mnemonic roles. |
